Coprocessing of the excipients is done for the production of the higher quality excipients. The aim of present work is the development of the Tramadol (Opioid analgesic) oro-dispersible tablets by using co-processing excipients. Oro-dispersible tablets are easier for the administration in pediatrics, geriatrics, and bedridden, nauseous or non-compliant patients. Coprocessed excipients were prepared by using spray dryer. Prepared coprocessed were utilized for the formulation of the oro-dispersible tablats. Prepared coprocessed excipients show better flow properties than the conventional excipients. Tablets formulated by using coprocessed excipients were compared with marketed formulations and it is concluded that tablets prepared from the coprocessing of the excipients show better drug release profile than the marketed one.
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